![]() Furthermore, ultrasound seems to detect a higher number of calcium pyrophosphate deposits than conventional radiology, even when using a more restrictive reference standard.Ĭalcium pyrophosphate deposition (CPPD) is a chronic arthropathy caused by the presence of calcium pyrophosphate (CPP) deposits in articular and periarticular tissues ( 1). The third sub-analysis showed a higher CPPD prevalence on ultrasound than conventional radiology at the knee (only data available).Ĭonclusion: Among all peripheral joints, the knees and wrists could be regarded as the target joints for CPPD detection by imaging. The knee had the highest prevalence for RQ1 and RQ2 by both conventional radiology and ultrasound, followed by the wrist with the highest prevalence for RQ1. Twenty-two and seventy-two papers were included in RQ1 and RQ2, respectively. Results: One-thousand eight hundred and twenty-seven manuscripts were identified, of which 94 articles were finally included. For the meta-analysis, the first, second, and third sub-analysis included studies with the knee, and knee or wrist as the index joint for CPPD (without restrictions on the reference standard) and synovial fluid analysis or histology as a reference standard (without restrictions on the index joint), respectively. Methods: A systematic literature search was performed in PubMed and Embase using pre-defined search strategies from inception to April 2021 to identify studies that evaluated conventional radiology and ultrasound in detecting CPPD at peripheral joints, including definite or suspected CPPD. Objectives: To identify the prevalence of calcium pyrophosphate crystal deposition (CPPD) using ultrasound and conventional radiology at peripheral joints in patients with suspected or definite CPPD. 13Rheumatology, Fondazione Policlinico Universitario “Gemelli”, IRCCS, Rome, Italy.12Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.11Rheumatology Department, Instituto Nacional de Rehabilitacion, Mexico, Mexico. ![]()
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